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KMID : 0363620080290010156
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 1 p.156 ~ p.166
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Study on Pharmacological Activity of Sipjeondaebotang by Difference in Component Ratio between Astragali Radix and Cinnamomi Cortex
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Lee Ho-Young
Ha Hye-Kyeong
Jung Da-Young
Choi Ji-Yoon
Lee Nam-Hun
Ma Jin-Yeul
Yu Young-Beob
Shin Hyeun-Kyoo
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Abstract
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Objective: Pamooltang (PM) and Sipjeondaebotang (SC) are used in Korea to treat many diseases such as sterility, menstrual disorder, and general prostration. We made a comparative study of PM and SC which are different in
component ratio between Astragalus membranaceus BUNGE (AC) and Cinnamomum cassia PRESL. (CC).
Methods: Anti-oxidation was studied by 1.1.-diphenyl-2-picrylhydrazyl (DPPH) assay and anti-inflammation was
investigated by prostaglandin E2 (PGE2) and nitric oxide (NO) inhibition assay. For immune response activities, this study used NO synthesis on RAW 264.7 cells and splenocyte proliferation.
Results: The results showed that PM and SC components had no significant effect of anti-oxidation or anti-inflammation. However, we observed their effects upon inducible NO synthesis in Raw 264.7 cells. The SC2 stimulated NO synthesis 11.42±1.36 μM (control; 0.89±0.00 μM). PM and SC components had the effect of immune response which in a dose-dependent manner significantly induced the splenocyte proliferation. The splenocyte proliferation induced by SC2 was higher than others at the concentration of 1, 10, 100, 1000 and 2000 μg/ml. The SC8 was shown to up-regulate IgG, 100 μg/ml 3.3 times, 1000 μg/ml 2.6 times as a control.
Conclusions: These results may have important implications for our understanding of the ratios of AC and CC in SC.
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KEYWORD
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Sipjeondaebotang, Pamooltang, NO synthesis, splenocyte
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